An optical data sensing device of a biological information measuring device, comprising: an optical sensor; a first light emitting device, configured to emit first light away from the optical sensor; and a first opaque isolation component, located between the optical sensor and the first light emitting device, configured to reduce the first light received by the optical sensor. The present invention also discloses an optical data sensing device comprising a plurality of light emitting devices with different emitting directions or wavelengths, to improve the accuracy of biological information measuring.