A knee joint prosthesis may be for implantation in a knee of a patient. The knee prosthesis may comprise a tibial component configured to be implanted on the tibia and a femoral component configured to be implanted on the femur. The femoral component may comprise a medial condyle with a medial articulation surface and a lateral condyle with a lateral articulation surface. The medial articulation surface and the lateral articulation surface may be shaped substantially symmetrically to each other across a femoral component plane bisecting the femoral component. The tibial component may comprise an articulation surface with a medial articulation side configured to articulate with the medial articulation surface and a lateral articulation side configured to articulate with the lateral articulation surface. The medial articulation side and the lateral articulation side may be shaped substantially asymmetrically to each other across a tibial component plane bisecting the tibial component.