- 专利标题： Pyridine derivatives and their use as sodium channel activators
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申请号： US17951640申请日： 2022-09-23
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公开(公告)号： US12054486B2公开(公告)日： 2024-08-06
- 发明人: Verner Alexander Lofstrand , Jung Yun Kim , Helen Clement , Kristen Nicole Burford , Paul Charifson , Shawn Johnstone , Juliette Sabbatani , Jan Felix Scholtes , Wei Zhang , Shaoyi Sun
- 申请人： Xenon Pharmaceuticals Inc.
- 申请人地址： CA Burnaby
- 专利权人： Xenon Pharmaceuticals Inc.
- 当前专利权人： Xenon Pharmaceuticals Inc.
- 当前专利权人地址： CA Burnaby
- 代理机构： Sterne, Kessler, Goldstein & Fox P.L.L.C.
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; C07D401/04 ; C07D401/14 ; C07D413/14 ; C07D487/04 ; C07D491/052
摘要：
The present disclosure is directed to compounds of formula (1):
wherein X, Y, R1, R2 and R3 are as described herein, as stereoisomers, enantiomers or tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, and pharmaceutical compositions comprising the compounds of formula (I), as described herein, which are useful as voltage-gated sodium channel modulators and are therefore are useful in treating seizure disorders such as epilepsy.
wherein X, Y, R1, R2 and R3 are as described herein, as stereoisomers, enantiomers or tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, and pharmaceutical compositions comprising the compounds of formula (I), as described herein, which are useful as voltage-gated sodium channel modulators and are therefore are useful in treating seizure disorders such as epilepsy.
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