Invention Grant
![Substituted benzo[f]imidazo[1,5-a][1,4]diazepines as GABA(a) receptor modulators](/docs/US/2024-08-06/US12054491B2/abs.jpg.600x600.jpg)
- Patent Title: Substituted benzo[f]imidazo[1,5-a][1,4]diazepines as GABA(a) receptor modulators
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Application No.: US17886403Application Date: 2022-08-11
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Publication No.: US12054491B2Publication Date: 2024-08-06
- Inventor: Alexander E. Arnold , Douglas C. Stafford , James M. Cook , Charles W. Emala , Gloria Forkuo , Rajwana Jahan , Revathi Kodali , Guanguan Li , Michael Rajesh Stephen
- Applicant: UWM Research Foundation, Inc. , The Trustees of Columbia University in the City of New York
- Applicant Address: US WI Milwaukee
- Assignee: UWM Research Foundation, Inc.,The Trustees of Columbia University in the City of New York
- Current Assignee: UWM Research Foundation, Inc.,The Trustees of Columbia University in the City of New York
- Current Assignee Address: US WI Milwaukee; US NY New York
- Agency: Michael Best & Friedrich LLP
- The original application number of the division: US16325080 2019.02.12
- Main IPC: C07D487/04
- IPC: C07D487/04 ; A61P11/06 ; C07D487/14
![Substituted benzo[f]imidazo[1,5-a][1,4]diazepines as GABA(a) receptor modulators](/abs-image/US/2024/08/06/US12054491B2/abs.jpg.150x150.jpg)
Abstract:
The present invention describes substituted benzo[f]imidazo[1,5-a][1,4]diazepines of the formula (I):
wherein R1, R2, R2′, R3, and X are as disclosed herein. These compounds target alpha-4 and alpha-5 GABAa receptors and are useful for the treatment of airway hyperresponsiveness and inflammation in asthma.
wherein R1, R2, R2′, R3, and X are as disclosed herein. These compounds target alpha-4 and alpha-5 GABAa receptors and are useful for the treatment of airway hyperresponsiveness and inflammation in asthma.
Public/Granted literature
- US20230103216A1 GABA(A) RECEPTOR MODULATORS AND METHODS TO CONTROL AIRWAY HYPERRESPONSIVENESS AND INFLAMMATION IN ASTHMA Public/Granted day:2023-03-30
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