- 专利标题： High-transduction-efficiency rAAV vectors, compositions, and methods of use
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申请号： US17810729申请日： 2022-07-05
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公开(公告)号： US12065467B2公开(公告)日： 2024-08-20
- 发明人: Arun Srivastava , George Vladimirovich Aslanidi , Kim M. Van Vliet , Mavis Agbandje-McKenna
- 申请人： University of Florida Research Foundation, Incorporated
- 申请人地址： US FL Gainesville
- 专利权人： University of Florida Research Foundation, Incorporated
- 当前专利权人： University of Florida Research Foundation, Incorporated
- 当前专利权人地址： US FL Gainesville
- 代理机构： Wolf, Greenfield & Sacks, P.C.
- 分案原申请号： US15444235 2017.02.27
- 主分类号： C12N7/00
- IPC分类号： C12N7/00 ; C07K14/005 ; C12N15/86
摘要：
The present invention provides AAV capsid proteins comprising modification of one or a combination of the surface-exposed lysine, serine, threonine and/or tyrosine residues in the VP3 region. Also provided are rAAV virions comprising the AAV capsid proteins of the present invention, as well as nucleic acid molecules and rAAV vectors encoding the AAV capsid proteins of the present invention. Advantageously, the rAAV vectors and virions of the present invention have improved efficiency in transduction of a variety of cells, tissues and organs of interest, when compared to wild-type rAAV vectors and virions.
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