Disclosure provides a display substrate, a display panel and a display device. The display substrate includes a substrate, a drive circuit layer and a light emitting device layer sequentially on the substrate, a display region of the substrate includes first and second display regions on a side of the first display region, light transmittance of the first display region is larger than that of the second display region; the drive circuit layer includes first pixel circuits in bezel region around the display region, second pixel circuits in the second display region; the light emitting device layer includes first light emitting devices, second light emitting devices; each first light emitting device is electrically connected with each first pixel circuit; each second light emitting device is electrically connected with each second pixel circuits; a density of the first light emitting devices is same as a density of the second light emitting devices.