- 专利标题: Method of making an osteoconductive polymer article and an osteoconductive polymer article thus made
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申请号: US17849893申请日: 2022-06-27
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公开(公告)号: US12076463B2公开(公告)日: 2024-09-03
- 发明人: Jens Christoph Thies , Ruud Jozef Regina Wilhelmus Peters , Pieter J. Emans , Jacob Koenen
- 申请人: DSM IP Assets B.V. , ACADEMISCH ZIEKENHUIS MAASTRICHT
- 申请人地址: NL Heerlen
- 专利权人: DSM IP Assets B.V.
- 当前专利权人: DSM IP Assets B.V.
- 当前专利权人地址: NL
- 代理商 Kevin M. Bull
- 优先权: EP 195323 2017.10.06
- 主分类号: A61L27/46
- IPC分类号: A61L27/46 ; A61L27/44 ; A61L27/54 ; A61L27/56 ; C08L75/04
摘要:
The disclosure relates to methods of making an osteoconductive polymer article for use as an orthopedic implant comprises steps of forming an article from a biocompatible, non-biodegradable polymer, the article comprising a non-flat surface with roughness Ra of at least 5 μm; providing a dispersion of bioactive ceramic particles of particle size at most 10 μm in a first solvent comprising a solvent for the polymer; coating at least the non-flat surface with the dispersion in at least one step; and rinsing the coated article with a second solvent being a non-solvent for the polymer to substantially remove the first solvent.
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