- 专利标题： Substituted piperazines as KRAS G12C inhibitors
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申请号： US17579359申请日： 2022-01-19
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公开(公告)号： US12083121B2公开(公告)日： 2024-09-10
- 发明人: John Gordon Allen , Brian Alan Lanman , Jian Chen , Anthony B. Reed , Victor J. Cee , Longbin Liu , Patricia Lopez , Ryan Paul Wurz , Thomas T. Nguyen , Shon Booker , Jennifer Rebecca Allen , Margaret Chu-Moyer , Albert Amegadzie , Ning Chen , Clifford Goodman , Jonathan D. Low , Vu Van Ma , Ana Elena Minatti , Nobuko Nishimura , Alexander J. Pickrell , Hui-Ling Wang , Youngsook Shin , Aaron C. Siegmund , Kevin C. Yang , Nuria A. Tamayo , Mary Walton , Qiufen Xue
- 申请人： AMGEN INC.
- 申请人地址： US CA Thousand Oaks
- 专利权人： Amgen Inc.
- 当前专利权人： Amgen Inc.
- 当前专利权人地址： US CA Thousand Oaks
- 代理商 Markus Bergauer
- 分案原申请号： US16438349 2019.06.11
- 主分类号： C07D241/04
- IPC分类号： C07D241/04 ; A61K31/519 ; A61K31/551 ; A61K39/395 ; A61P35/00
摘要：
Provided herein are KRAS G12C inhibitors, such as
composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
公开/授权文献
- US20220175782A1 KRAS G12C INHIBITORS AND METHODS OF USING THE SAME 公开/授权日：2022-06-09
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