Invention Grant
- Patent Title: Substituted piperazines as KRAS G12C inhibitors
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Application No.: US17579359Application Date: 2022-01-19
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Publication No.: US12083121B2Publication Date: 2024-09-10
- Inventor: John Gordon Allen , Brian Alan Lanman , Jian Chen , Anthony B. Reed , Victor J. Cee , Longbin Liu , Patricia Lopez , Ryan Paul Wurz , Thomas T. Nguyen , Shon Booker , Jennifer Rebecca Allen , Margaret Chu-Moyer , Albert Amegadzie , Ning Chen , Clifford Goodman , Jonathan D. Low , Vu Van Ma , Ana Elena Minatti , Nobuko Nishimura , Alexander J. Pickrell , Hui-Ling Wang , Youngsook Shin , Aaron C. Siegmund , Kevin C. Yang , Nuria A. Tamayo , Mary Walton , Qiufen Xue
- Applicant: AMGEN INC.
- Applicant Address: US CA Thousand Oaks
- Assignee: Amgen Inc.
- Current Assignee: Amgen Inc.
- Current Assignee Address: US CA Thousand Oaks
- Agent Markus Bergauer
- The original application number of the division: US16438349 2019.06.11
- Main IPC: C07D241/04
- IPC: C07D241/04 ; A61K31/519 ; A61K31/551 ; A61K39/395 ; A61P35/00
Abstract:
Provided herein are KRAS G12C inhibitors, such as
composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
Public/Granted literature
- US20220175782A1 KRAS G12C INHIBITORS AND METHODS OF USING THE SAME Public/Granted day:2022-06-09
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