Computer readable media for predicting a tooth shape for at least partially un-erupted teeth and dental appliances formed therefrom. In some examples, methods include generating orthoscopic views of virtual representations of an identified tooth type in different orthogonal directions, representing bounding shapes around the orthoscopic views, and applying principal component analysis on the bounding shapes to predict a tooth shape. In some examples, methods include generating a spherical harmonic signature for virtual representations of an identified tooth type, calculating a distance between spherical harmonic signatures to predict the tooth shape. The predicted tooth shape of the at least partially un-erupted tooth may be incorporated into virtual dentition model(s) of a dentition in accordance with an orthodontic treatment plan for treating the dentition.