A pixel structure, a driving method thereof, a display panel, and a display apparatus are provided. The pixel structure includes: a plurality of pixel rows and a plurality of pixel columns. Each pixel row includes: sub-pixels of four different colors. The plurality of pixel columns include: a plurality of first pixel columns and a plurality of second pixel columns arranged alternately. Each of the first pixel columns includes: sub-pixels of three of the four different colors. Each of the second pixel columns includes: sub-pixels of another color other than the three of the four different colors.