Invention Grant
- Patent Title: WD40 repeat domain protein 5 (WDR5) degradation/disruption compounds and methods of use
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Application No.: US17254345Application Date: 2019-06-21
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Publication No.: US12110295B2Publication Date: 2024-10-08
- Inventor: Jian Jin , Gang Wang , Jing Liu , Xufen Yu , Dongxu Li
- Applicant: Icahn School of Medicine at Mount Sinai , The University of North Carolina at Chapel Hill
- Applicant Address: US NY New York
- Assignee: Icahn School of Medicine at Mount Sinai,The University of North Carolina at Chapel Hill
- Current Assignee: Icahn School of Medicine at Mount Sinai,The University of North Carolina at Chapel Hill
- Current Assignee Address: US NY New York; US NC Chapel Hill
- Agency: Fish & Richardson P.C.
- International Application: PCT/US2019/038560 2019.06.21
- International Announcement: WO2019/246570A 2019.12.26
- Date entered country: 2020-12-21
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D401/14 ; C07D417/14
Abstract:
Disclosed herein are WD40 repeat domain protein 5 (WDR5) degradation/disruption compounds including a WDR5 ligand, a degradation/disruption tag, and a linker, and methods of using such compounds in the treatment of WDR5-mediated diseases.
Public/Granted literature
- US11905291B2 WD40 repeat domain protein 5 (WDR5) degradation/disruption compounds and methods of use Public/Granted day:2024-02-20
Information query
