公开(公告)号：US11905291B2

公开(公告)日：2024-02-20

申请号：US17254345

申请日：2019-06-21

申请人： Icahn School of Medicine at Mount Sinai ,  The University of North Carolina at Chapel Hill

发明人： Jian Jin ,  Gang Wang ,  Jing Liu ,  Xufen Yu ,  Dongxu Li

IPC分类号： C07D487/04 ,  C07D401/14 ,  C07D417/14

CPC分类号： C07D487/04 ,  C07D401/14 ,  C07D417/14

摘要： Disclosed herein are WD40 repeat domain protein 5 (WDR5) degradation/disruption compounds including a WDR5 ligand, a degradation/disruption tag, and a linker, and methods of using such compounds in the treatment of WDR5-mediated diseases.

公开(公告)号：US12110295B2

公开(公告)日：2024-10-08

申请号：US17254345

申请日：2019-06-21

申请人： Icahn School of Medicine at Mount Sinai ,  The University of North Carolina at Chapel Hill

发明人： Jian Jin ,  Gang Wang ,  Jing Liu ,  Xufen Yu ,  Dongxu Li

IPC分类号： C07D487/04 ,  C07D401/14 ,  C07D417/14

CPC分类号： C07D487/04 ,  C07D401/14 ,  C07D417/14

摘要： Disclosed herein are WD40 repeat domain protein 5 (WDR5) degradation/disruption compounds including a WDR5 ligand, a degradation/disruption tag, and a linker, and methods of using such compounds in the treatment of WDR5-mediated diseases.

公开(公告)号：US20220348580A1

公开(公告)日：2022-11-03

申请号：US17254345

申请日：2019-06-21

申请人： Icahn School of Medicine at Mount Sinai ,  The University of North Carolina at Chapel Hill

发明人： Jian Jin ,  Gang Wang ,  Jing Liu ,  Xufen Yu ,  Dongxu Li

IPC分类号： C07D487/04 ,  C07D401/14 ,  C07D417/14

摘要： Disclosed herein are WD40 repeat domain protein 5 (WDR5) degradation/disruption compounds including a WDR5 ligand, a degradation/disruption tag, and a linker, and methods of using such compounds in the treatment of WDR5-mediated diseases.

公开(公告)号：US11472799B2

公开(公告)日：2022-10-18

申请号：US16977654

申请日：2019-03-06

申请人： Icahn School of Medicine at Mount Sinai

发明人： Jian Jin ,  Jing Liu ,  Ramon E. Parsons ,  Jia Xu ,  Xufen Yu

IPC分类号： C07D417/14 ,  C07D401/14 ,  C07D487/04 ,  G01N33/50 ,  A61P35/00 ,  A61K31/436 ,  A61K31/496 ,  A61K31/517 ,  A61K31/519 ,  A61K45/06

摘要： Disclosed herein are serine threonine kinase (AKT) degradation/disruption compounds including an AKT ligand, a degradation/disruption tag, and a linker, and methods of using such compounds in the treatment of AKT-mediated diseases.

公开(公告)号：US20230167106A1

公开(公告)日：2023-06-01

申请号：US17938502

申请日：2022-10-06

申请人： Icahn School of Medicine at Mount Sinai

发明人： Jian Jin ,  Jing Liu ,  Ramon E. Parsons ,  Jia Xu ,  Xufen Yu

IPC分类号： C07D417/14 ,  A61P35/00 ,  A61K31/436 ,  A61K31/496 ,  A61K31/517 ,  A61K31/519 ,  A61K45/06 ,  C07D401/14 ,  C07D487/04 ,  G01N33/50

CPC分类号： C07D417/14 ,  A61P35/00 ,  A61K31/436 ,  A61K31/496 ,  A61K31/517 ,  A61K31/519 ,  A61K45/06 ,  C07D401/14 ,  C07D487/04 ,  G01N33/5011 ,  G01N2333/90 ,  G01N2333/912

摘要： Disclosed herein are serine threonine kinase (AKT) degradation/disruption compounds including an AKT ligand, a degradation/disruption tag, and a linker, and methods of using such compounds in the treatment of AKT-mediated diseases.