- 专利标题: Amorphous calcium carbonate stabilized with polyphosphates or bisphosphonates
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申请号: US17343471申请日: 2021-06-09
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公开(公告)号: US12115184B2公开(公告)日: 2024-10-15
- 发明人: Yosef Ben , Yigal Dov Blum , Hagay Moshe , Ben Ashkenazi
- 申请人: AMORPHICAL LTD.
- 申请人地址: IL Ness Ziona
- 专利权人: AMORPHICAL LTD.
- 当前专利权人: AMORPHICAL LTD.
- 当前专利权人地址: US IL Ness Ziona
- 代理机构: Dorsey & Whitney LLP
- 分案原申请号: US15579010
- 主分类号: A61K33/10
- IPC分类号: A61K33/10 ; A61K9/00 ; A61K9/10 ; A61K9/14 ; A61K47/24 ; A61P31/00 ; A61P35/00
摘要:
The present invention provides solid compositions of amorphous calcium carbonate (ACC) and a polyphosphate, bisphosphonate or pharmaceutical salts thereof as a stabilizer. Said stabilizers stabilizes the ACC and prevent crystallization to crystalline calcium carbonate (CCC) for a long period of time, even in an aqueous suspension. The invention further provides pharmaceutical composition comprising the solid ACC compositions as well their use in treating of certain diseases and conditions.
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