公开(公告)号：US12115184B2

公开(公告)日：2024-10-15

申请号：US17343471

申请日：2021-06-09

Applicant: AMORPHICAL LTD.

Inventor： Yosef Ben ,  Yigal Dov Blum ,  Hagay Moshe ,  Ben Ashkenazi

IPC: A61K33/10 ,  A61K9/00 ,  A61K9/10 ,  A61K9/14 ,  A61K47/24 ,  A61P31/00 ,  A61P35/00

CPC classification number: A61K33/10 ,  A61K9/0019 ,  A61K9/0056 ,  A61K9/0073 ,  A61K9/10 ,  A61K9/143 ,  A61K47/24 ,  A61P31/00 ,  A61P35/00

Abstract: The present invention provides solid compositions of amorphous calcium carbonate (ACC) and a polyphosphate, bisphosphonate or pharmaceutical salts thereof as a stabilizer. Said stabilizers stabilizes the ACC and prevent crystallization to crystalline calcium carbonate (CCC) for a long period of time, even in an aqueous suspension. The invention further provides pharmaceutical composition comprising the solid ACC compositions as well their use in treating of certain diseases and conditions.

公开(公告)号：US20250017957A1

公开(公告)日：2025-01-16

申请号：US18901396

申请日：2024-09-30

Applicant: AMORPHICAL LTD.

Inventor： Yosef Ben ,  Yigal Dov Blum ,  Hagay Moshe ,  Ben Ashkenazi

IPC: A61K33/10 ,  A61K9/00 ,  A61K9/10 ,  A61K9/14 ,  A61K47/24 ,  A61P31/00 ,  A61P35/00

Abstract: The present invention provides solid compositions of amorphous calcium carbonate (ACC) and a polyphosphate, bisphosphonate or pharmaceutical salts thereof as a stabilizer. Said stabilizers stabilizes the ACC and prevent crystallization to crystalline calcium carbonate (CCC) for a long period of time, even in an aqueous suspension. The invention further provides pharmaceutical composition comprising the solid ACC compositions as well their use in treating of certain diseases and conditions.

公开(公告)号：US20210308178A1

公开(公告)日：2021-10-07

申请号：US17343471

申请日：2021-06-09

Applicant: AMORPHICAL LTD.

Inventor： Yosef Ben ,  Yigal Dov Blum ,  Hagay Moshe ,  Ben Ashkenazi

IPC: A61K33/10 ,  A61K9/00 ,  A61K9/10 ,  A61P31/00 ,  A61P35/00 ,  A61K9/14 ,  A61K47/24

Abstract: The present invention provides solid compositions of amorphous calcium carbonate (ACC) and a polyphosphate, bisphosphonate or pharmaceutical salts thereof as a stabilizer. Said stabilizers stabilizes the ACC and prevent crystallization to crystalline calcium carbonate (CCC) for a long period of time, even in an aqueous suspension. The invention further provides pharmaceutical composition comprising the solid ACC compositions as well their use in treating of certain diseases and conditions.

公开(公告)号：US11052107B2

公开(公告)日：2021-07-06

申请号：US15579010

申请日：2016-06-02

Applicant: AMORPHICAL LTD.

Inventor： Yosef Ben ,  Yigal Dov Blum ,  Hagay Moshe ,  Ben Ashkenazi

IPC: A61K9/10 ,  A61K9/14 ,  A61K33/10 ,  A61K47/24 ,  A61K9/00 ,  A61P31/00 ,  A61P35/00

Abstract: The present invention provides solid compositions of amorphous calcium carbonate (ACC) and a polyphosphate, bisphosphonate or pharmaceutical salts thereof as a stabilizer. Said stabilizers stabilizes the ACC and prevent crystallization to crystalline calcium carbonate ((′( (″) for a long period of time, even in an aqueous suspension. The invention further provides pharmaceutical composition comprising the solid ACC compositions as well their use in treating of certain diseases and conditions.

公开(公告)号：US20180140631A1

公开(公告)日：2018-05-24

申请号：US15579010

申请日：2016-06-02

Applicant: AMORPHICAL LTD.

Inventor： Yosef Ben ,  Yigal Dov Blum ,  Hagay Moshe ,  Ben Ashkenazi

IPC: A61K33/10 ,  A61K47/24 ,  A61K9/14

CPC classification number: A61K33/10 ,  A61K9/0019 ,  A61K9/0056 ,  A61K9/0073 ,  A61K9/10 ,  A61K9/143 ,  A61K47/24 ,  A61P31/00 ,  A61P35/00

Abstract: The present invention provides solid compositions of amorphous calcium carbonate (ACC) and a polyphosphate, bisphosphonate or pharmaceutical salts thereof as a stabilizer. Said stabilizers stabilizes the ACC and prevent crystallization to crystalline calcium carbonate ((′((″) for a long period of time, even in an aqueous suspension. The invention further provides pharmaceutical composition comprising the solid ACC compositions as well their use in treating of certain diseases and conditions.