- 专利标题： Mass spectrometry method for measuring thiamine in body fluid
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申请号： US16989545申请日： 2020-08-10
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公开(公告)号： US12116617B2公开(公告)日： 2024-10-15
- 发明人: Sum Chan , Qibo Jiang , Richard E. Reitz
- 申请人： Quest Diagnostics Investments Incorporated
- 申请人地址： US DE Wilmington
- 专利权人： Quest Diagnostics Investments Incorporated
- 当前专利权人： Quest Diagnostics Investments Incorporated
- 当前专利权人地址： US DE Wilmington
- 代理机构： Foley & Lardner LLP
- 主分类号： C12Q1/42
- IPC分类号： C12Q1/42 ; G01N33/82
摘要：
Provided are methods for determining the amount of total thiamine in a body fluid sample using liquid chromatography and mass spectrometry. Total thiamine is converted to free thiamine by treatment with an acid phosphatase prior to thiamine separation and quantification.
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