公开(公告)号：US12116617B2

公开(公告)日：2024-10-15

申请号：US16989545

申请日：2020-08-10

申请人： Quest Diagnostics Investments Incorporated

发明人： Sum Chan ,  Qibo Jiang ,  Richard E. Reitz

IPC分类号： C12Q1/42 ,  G01N33/82

CPC分类号： C12Q1/42 ,  G01N33/82

摘要： Provided are methods for determining the amount of total thiamine in a body fluid sample using liquid chromatography and mass spectrometry. Total thiamine is converted to free thiamine by treatment with an acid phosphatase prior to thiamine separation and quantification.

公开(公告)号：US20240248099A1

公开(公告)日：2024-07-25

申请号：US18562768

申请日：2022-05-20

申请人： BELITE BIO, LLC

发明人： Webber LIAO ,  Cheng-Chi Irene WANG ,  Yu-Hsin Tom LIN

IPC分类号： G01N33/68 ,  A61K31/4545 ,  A61P27/02 ,  C12Q1/6883 ,  G01N33/82

CPC分类号： G01N33/6893 ,  A61K31/4545 ,  A61P27/02 ,  C12Q1/6883 ,  G01N33/82 ,  C12Q2600/118 ,  C12Q2600/156 ,  G01N2800/16 ,  G01N2800/50 ,  G01N2800/52

摘要： Provided herein are biomarkers and diagnostics useful in the diagnosis of age-related macular degeneration. Also provided herein are treatments for diseases including age-related macular degeneration.

公开(公告)号：US12013405B2

公开(公告)日：2024-06-18

申请号：US17510459

申请日：2021-10-26

申请人： Roche Diagnostics Operations, Inc.

发明人： Sascha Antoni ,  Christian Vogl

IPC分类号： G01N33/82 ,  C07C401/00

CPC分类号： G01N33/82 ,  C07C401/00 ,  Y10T436/203332

摘要： A reagent composition for releasing vitamin D compounds bound to vitamin D-binding protein and an in vitro method for the detection of a vitamin D compound in which the vitamin D compound is released from vitamin D-binding protein by the use of this reagent composition as well as the reagent mixture obtained in this manner. Also disclosed is the use of the reagent compositions to release vitamin D compounds as well as a kit for detecting a vitamin D compound.

公开(公告)号：US11946910B2

公开(公告)日：2024-04-02

申请号：US16973306

申请日：2019-06-11

申请人： TOKUYAMA CORPORATION ,  JEOL Ltd.

发明人： Masahiko Seki ,  Seketsu Fukuzawa ,  Masaki Takiwaki

IPC分类号： G01N30/06 ,  C07D487/08 ,  G01N33/82

CPC分类号： G01N30/06 ,  C07D487/08 ,  G01N33/82 ,  G01N2030/067

摘要： Provided are a stable triazolinedione adduct, a method for producing the same, a method for producing an ene compound, and a method for analyzing an ene compound. A triazolinedione adduct that is stable until the time of use and can be reacted while reverting to a triazolinedione compound at the time of use. Specifically, a triazolinedione adduct represented by formula (1). (In the formula, R1 is an organic group, and A is a fused ring of three or more rings including at least one aromatic ring.)

公开(公告)号：US20240044864A1

公开(公告)日：2024-02-08

申请号：US18487654

申请日：2023-10-16

申请人： Quest Diagnostics Investments LLC

发明人： Changming Yang ,  Sum Chan

IPC分类号： G01N33/487 ,  G01N33/68 ,  G01N33/82 ,  G01N30/72 ,  H01J49/00

CPC分类号： G01N33/487 ,  G01N33/6848 ,  G01N33/82 ,  G01N30/72 ,  H01J49/0031 ,  G01N30/7233 ,  H01J49/0027 ,  H01J49/0054 ,  Y10T436/147777 ,  G01N2030/027

摘要： Methods are described for measuring the amount of a vitamin B2 in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying vitamin B2 in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric techniques.

公开(公告)号：US11885820B2

公开(公告)日：2024-01-30

申请号：US17408298

申请日：2021-08-20

申请人： Quest Diagnostics Investments Incorporated

发明人： Brett Holmquist ,  Nigel J. Clarke ,  Richard E Reitz

IPC分类号： G01N33/82 ,  G01N30/72 ,  G01N30/88 ,  H01J49/00

CPC分类号： G01N33/82 ,  G01N30/7233 ,  G01N30/88 ,  G01N2030/8813 ,  H01J49/0031 ,  H01J49/0045 ,  Y10T436/203332 ,  Y10T436/24

摘要： The invention relates to the detection of vitamin D metabolites. In a particular aspect, the invention relates to methods for detecting derivatized vitamin D metabolites by mass spectrometry.

公开(公告)号：US20240018586A1

公开(公告)日：2024-01-18

申请号：US18039631

申请日：2021-11-26

申请人： PXD Limited

发明人： David Langton

IPC分类号： C12Q1/6881 ,  G01N33/82

CPC分类号： C12Q1/6881 ,  G01N33/82 ,  G01N2333/70539 ,  G01N2800/50 ,  C12Q2600/172 ,  G01N2800/52

摘要： The present invention relates to methods, devices and kits for identifying individuals who are at increased risk of developing severe symptoms associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The present invention also relates to methods, devices and kits for identifying individuals who have a reduced risk of developing severe symptoms associated with SARS-CoV-2 infection. In particular, it relates to the use of HLA haplotypes as biomarkers to predict disease severity in individuals infected with SARS-CoV-2.

公开(公告)号：US20230420235A1

公开(公告)日：2023-12-28

申请号：US18466168

申请日：2023-09-13

申请人： Quest Diagnostics Investments Incorporated

发明人： Qibo Jiang ,  Sum Chan ,  Richard E Reitz

IPC分类号： H01J49/00 ,  G01N33/82 ,  G01N33/49

CPC分类号： H01J49/0031 ,  G01N33/82 ,  G01N33/49 ,  H01J49/004 ,  Y10T436/145555

摘要： Provided are methods of detecting the presence or amount of the active form of vitamin B6, pyridoxal 5′-phosphate, in a body fluid sample using tandem mass spectrometry coupled with liquid chromatography.

公开(公告)号：US20230375575A1

公开(公告)日：2023-11-23

申请号：US18364356

申请日：2023-08-02

申请人： Quest Diagnostics Investments Incorporated

发明人： Brett Holmquist ,  Nigel Clarke

IPC分类号： G01N33/82 ,  G01N33/68 ,  H01J49/00

CPC分类号： G01N33/82 ,  G01N33/6848 ,  G01N33/6851 ,  H01J49/0027 ,  Y10T436/212 ,  H01J49/00 ,  G01N2560/00

摘要： The invention relates to the quantitative measurement of steroidal compounds by mass spectrometry. In a particular aspect, the invention relates to methods for quantitative measurement of steroidal compounds from multiple samples by mass spectrometry.

公开(公告)号：US11821889B2

公开(公告)日：2023-11-21

申请号：US17715202

申请日：2022-04-07

申请人： Quest Diagnostics Investments Incorporated

发明人： Changming Yang ,  Sum Chan

IPC分类号： G01N33/487 ,  G01N30/72 ,  H01J49/00 ,  G01N33/68 ,  G01N33/82 ,  G01N30/02

CPC分类号： G01N33/487 ,  G01N30/72 ,  G01N30/7233 ,  G01N33/6848 ,  G01N33/82 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/0054 ,  G01N2030/027 ,  Y10T436/147777

摘要： Methods are described for measuring the amount of a vitamin B2 in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying vitamin B2 in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric techniques.