This disclosure is directed toward systems and methods of pre-multiplied alpha handling during image processing operations. The image processing circuitry may include hardware that enables removal and insertion of pre-multiplied alpha content into red, green, blue (RGB) pixel values during gamma and scaling operations. The division by alpha and multiplication by alpha hardware may enable removal of pre-multiplied alpha content to RGB pixel values prior to gamma operations and insertion of pre-multiplied alpha content into RGB pixel values prior to scaling operations.