- 专利标题： PARG inhibitory compounds
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申请号： US17204206申请日： 2021-03-17
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公开(公告)号： US12129236B2公开(公告)日： 2024-10-29
- 发明人: Alison E. McGonagle , Allan M. Jordan , Bohdan Waszkowycz , Colin P. Hutton , Ian D. Waddell , James R. Hitchin , Kate M. Smith , Niall M. Hamilton
- 申请人： CANCER RESEARCH TECHNOLOGY LIMITED
- 申请人地址： GB London
- 专利权人： CANCER RESEARCH TECHNOLOGY LIMITED
- 当前专利权人： CANCER RESEARCH TECHNOLOGY LIMITED
- 当前专利权人地址： GB London
- 代理机构： Mintz Levin Cohn Ferris Glovsky and Popeo PC
- 优先权： GB 22771 2014.12.19
- 分案原申请号： US15533819
- 主分类号： C07D235/26
- IPC分类号： C07D235/26 ; A61P35/00 ; C07D307/85 ; C07D401/06 ; C07D403/04 ; C07D403/06 ; C07D405/04 ; C07D405/06 ; C07D409/04 ; C07D413/04 ; C07D413/06 ; C07D413/14 ; C07D417/04 ; C07D417/06 ; C07D417/14
摘要：
The present invention relates to compounds of formula I that function as inhibitors of PARG (Poly ADP-ribose glycohydrolase) enzyme activity: wherein R1a, R1b, R1c, R1d, W, X1, X2, X3, X4, X5, X6, X7, c are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which PARG activity is implicated.
公开/授权文献
- US20210380539A1 PARG INHIBITORY COMPOUNDS 公开/授权日：2021-12-09
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