Systems and methods for centralized client application management are provided. In an example embodiment, a client state is received from a mobile device at a management device. The client state comprises information about a particular application. A first instruction for the mobile device is generated by one or more hardware processors. The first instruction comprises an instruction to the mobile device to prevent user interaction with a user interface of a particular application. The first instruction is communicated to the mobile device, and the mobile device performs the first instruction to prevent user interaction with the user interface of the particular application.