Invention Grant
- Patent Title: Degradable polyethylene glycol derivative
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Application No.: US17042711Application Date: 2019-03-29
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Publication No.: US12187846B2Publication Date: 2025-01-07
- Inventor: Hiroki Yoshioka , Masaki Kamiya , Yuji Yamamoto , Midori Hirai , Akiko Sasaki , Nobuhiro Nishiyama , Makoto Matsui , Hiroyasu Takemoto , Kazuki Miyauchi , Takahiro Nomoto , Keishiro Tomoda
- Applicant: NOF CORPORATION , TOKYO INSTITUTE OF TECHNOLOGY
- Applicant Address: JP Tokyo; JP Tokyo
- Assignee: NOF CORPORATION,TOKYO INSTITUTE OF TECHNOLOGY
- Current Assignee: NOF CORPORATION,TOKYO INSTITUTE OF TECHNOLOGY
- Current Assignee Address: JP Tokyo; JP Tokyo
- Agency: Leydig, Voit & Mayer, Ltd.
- Priority: JP2018-064305 20180329
- International Application: PCT/JP2019/014246 WO 20190329
- International Announcement: WO2019/189854 WO 20191003
- Main IPC: C08G65/333
- IPC: C08G65/333 ; A61K47/60 ; A61K47/62 ; A61K47/65 ; C08G65/325 ; C08L71/02

Abstract:
The invention provides a high-molecular-weight polyethylene glycol derivative that does not cause vacuolation of cells. The degradable polyethylene glycol derivative is represented by the following formula (1): wherein m is 1-7, n1 and n2 are each independently 45-682, p is 1-4, R is an alkyl group having 1-4 carbon atoms, Z is an oligopeptide with 2-8 residues composed of neutral amino acids excluding cysteine, Q is a residue of a compound having 2-5 active hydrogens, X is a functional group capable of reacting with a bio-related substance, and L1, L2, L3, L4 and L5 are each independently a single bond or a divalent spacer.
Public/Granted literature
- US20210147624A1 DEGRADABLE POLYETHYLENE GLYCOL DERIVATIVE Public/Granted day:2021-05-20
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