公开(公告)号：US12239713B2

公开(公告)日：2025-03-04

申请号：US17042039

申请日：2019-03-29

Applicant: NOF CORPORATION ,  TOKYO INSTITUTE OF TECHNOLOGY

Inventor： Hiroki Yoshioka ,  Masaki Kamiya ,  Yuji Yamamoto ,  Midori Hirai ,  Akiko Sasaki ,  Nobuhiro Nishiyama ,  Makoto Matsui ,  Hiroyasu Takemoto ,  Kazuki Miyauchi ,  Takahiro Nomoto ,  Keishiro Tomoda

IPC: A61K47/60 ,  A61K38/19 ,  A61K38/23 ,  A61K38/27 ,  C07K5/103 ,  C07K7/06 ,  C07K19/00 ,  C08G65/333

Abstract: The invention provides a bio-related substance bonded to a high-molecular-weight polyethylene glycol derivative that does not cause vacuolation of cells. The bio-related substance bonded to a degradable polyethylene glycol derivative is represented by the formula (A): wherein m is 1-7, n1 and n2 are each independently 45-682, p is 1-4, R is an alkyl group having 1-4 carbon atoms, Z is an oligopeptide with 2-8 residues composed of neutral amino acids excluding cysteine, Q is a residue of a compound having 2-5 active hydrogens, D is the bio-related substance, L1, L2, L3, L4 and L5 are each independently a single bond or a divalent spacer, and y is 1-40.

公开(公告)号：US12187846B2

公开(公告)日：2025-01-07

申请号：US17042711

申请日：2019-03-29

Applicant: NOF CORPORATION ,  TOKYO INSTITUTE OF TECHNOLOGY

Inventor： Hiroki Yoshioka ,  Masaki Kamiya ,  Yuji Yamamoto ,  Midori Hirai ,  Akiko Sasaki ,  Nobuhiro Nishiyama ,  Makoto Matsui ,  Hiroyasu Takemoto ,  Kazuki Miyauchi ,  Takahiro Nomoto ,  Keishiro Tomoda

IPC: C08G65/333 ,  A61K47/60 ,  A61K47/62 ,  A61K47/65 ,  C08G65/325 ,  C08L71/02

Abstract: The invention provides a high-molecular-weight polyethylene glycol derivative that does not cause vacuolation of cells. The degradable polyethylene glycol derivative is represented by the following formula (1): wherein m is 1-7, n1 and n2 are each independently 45-682, p is 1-4, R is an alkyl group having 1-4 carbon atoms, Z is an oligopeptide with 2-8 residues composed of neutral amino acids excluding cysteine, Q is a residue of a compound having 2-5 active hydrogens, X is a functional group capable of reacting with a bio-related substance, and L1, L2, L3, L4 and L5 are each independently a single bond or a divalent spacer.