Invention Grant
![Process for preparing 7H-pyrrolo[2,3-d]pyrimidine derivatives and synthetic intermediates thereof](/docs/US/2025-01-14/US12195481B2/abs.jpg.600x600.jpg)
- Patent Title: Process for preparing 7H-pyrrolo[2,3-d]pyrimidine derivatives and synthetic intermediates thereof
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Application No.: US18136661Application Date: 2023-04-19
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Publication No.: US12195481B2Publication Date: 2025-01-14
- Inventor: Hiromu Takiguchi , Akinobu Higashi , Takashi Inaba , Takashi Watanabe , Tsubasa Takeichi , Anders Klarskov Petersen , Per Vedsoe , Kim Lebek Jensen , Jan Bornholdt , Soren Ebdrup
- Applicant: JAPAN TOBACCO INC. , LEO Pharma A/S
- Applicant Address: JP Tokyo; DK Ballerup
- Assignee: JAPAN TOBACCO INC.,LEO Pharma A/S
- Current Assignee: JAPAN TOBACCO INC.,LEO Pharma A/S
- Current Assignee Address: JP Tokyo; DK Ballerup
- Agency: Fish & Richardson P.C.
- Priority: JP2016247607 20161221
- Main IPC: C07D519/00
- IPC: C07D519/00 ; C07C271/22 ; C07D487/10 ; C07C269/00 ; C07C269/06 ; C07D205/08 ; C07D307/33 ; C07D403/06 ; C07D491/10 ; C07D491/107
![Process for preparing 7H-pyrrolo[2,3-d]pyrimidine derivatives and synthetic intermediates thereof](/abs-image/US/2025/01/14/US12195481B2/abs.jpg.150x150.jpg)
Abstract:
The present invention provides processes for preparing 7H-pyrrolo[2,3-d]pyrimidine derivatives, which are useful as a Janus kinase (JAK) inhibitor, intermediates thereof, and processes for preparing the intermediates. The present invention provides processes for preparing 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile using salts of (3S,4R)-1-benzyl-3-methyl-1,6-diazaspiro[3.4]octane with organic acids.
Public/Granted literature
- US20240140967A1 PROCESS FOR PREPARING 7H-PYRROLO[2,3-d]PYRIMIDINE DERIVATIVES AND SYNTHETIC INTERMEDIATES THEREOF Public/Granted day:2024-05-02
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