公开(公告)号：US12195481B2

公开(公告)日：2025-01-14

申请号：US18136661

申请日：2023-04-19

Applicant: JAPAN TOBACCO INC. ,  LEO Pharma A/S

Inventor： Hiromu Takiguchi ,  Akinobu Higashi ,  Takashi Inaba ,  Takashi Watanabe ,  Tsubasa Takeichi ,  Anders Klarskov Petersen ,  Per Vedsoe ,  Kim Lebek Jensen ,  Jan Bornholdt ,  Soren Ebdrup

IPC: C07D519/00 ,  C07C271/22 ,  C07D487/10 ,  C07C269/00 ,  C07C269/06 ,  C07D205/08 ,  C07D307/33 ,  C07D403/06 ,  C07D491/10 ,  C07D491/107

Abstract: The present invention provides processes for preparing 7H-pyrrolo[2,3-d]pyrimidine derivatives, which are useful as a Janus kinase (JAK) inhibitor, intermediates thereof, and processes for preparing the intermediates. The present invention provides processes for preparing 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile using salts of (3S,4R)-1-benzyl-3-methyl-1,6-diazaspiro[3.4]octane with organic acids.

公开(公告)号：US20240140967A1

公开(公告)日：2024-05-02

申请号：US18136661

申请日：2023-04-19

Applicant: JAPAN TOBACCO INC. ,  LEO Pharma A/S

Inventor： Hiromu Takiguchi ,  Akinobu Higashi ,  Takashi Inaba ,  Takashi Watanabe ,  Tsubasa Takeichi ,  Anders Klarskov Petersen ,  Per Vedsoe ,  Kim Lebek Jensen ,  Jan Bornholdt ,  Soren Ebdrup

IPC: C07D519/00 ,  C07C271/22 ,  C07D487/10

CPC classification number: C07D519/00 ,  C07C271/22 ,  C07D487/10 ,  C07B2200/13

Abstract: The present invention provides processes for preparing 7H-pyrrolo[2,3-d]pyrimidine derivatives, which are useful as a Janus kinase (JAK) inhibitor, intermediates thereof, and processes for preparing the intermediates. The present invention provides processes for preparing 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile using salts of (3S,4R)-1-benzyl-3-methyl-1,6-diazaspiro[3.4]octane with organic acids.

公开(公告)号：US11673900B2

公开(公告)日：2023-06-13

申请号：US16470888

申请日：2017-12-20

Applicant: JAPAN TOBACCO INC. ,  LEO Pharma A/S

Inventor： Hiromu Takiguchi ,  Akinobu Higashi ,  Takashi Inaba ,  Takashi Watanabe ,  Tsubasa Takeichi ,  Anders Klarskov Petersen ,  Per Vedsoe ,  Kim Lebek Jensen ,  Jan Bornholdt ,  Soren Ebdrup

IPC: C07D403/06 ,  C07D519/00 ,  C07D487/10 ,  C07D205/08 ,  C07D307/33 ,  C07C271/22 ,  C07C269/00 ,  C07C269/06 ,  C07D491/107 ,  C07D491/10

CPC classification number: C07D519/00 ,  C07C271/22 ,  C07D487/10 ,  C07B2200/13

Abstract: The present invention provides processes for preparing 7H-pyrrolo[2,3-d]pyrimidine derivatives, which are useful as a Janus kinase (JAK) inhibitor, intermediates thereof, and processes for preparing the intermediates. The present invention provides processes for preparing 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile using salts of (3S,4R)-1-benzyl-3-methyl-1,6-diazaspiro[3.4]octane with organic acids.

公开(公告)号：US20200216470A1

公开(公告)日：2020-07-09

申请号：US16470888

申请日：2017-12-20

Applicant: JAPAN TOBACCO INC. ,  LEO Pharma A/S

Inventor： Hiromu Takiguchi ,  Akinobu Higashi ,  Takashi Inaba ,  Takashi Watanabe ,  Tsubasa Takeichi ,  Anders Klarskov Petersen ,  Per Vedsoe ,  Kim Lebek Jensen ,  Jan Bornholdt ,  Soren Ebdrup

IPC: C07D519/00 ,  C07D487/10 ,  C07C271/22

Abstract: The present invention provides processes for preparing 7H-pyrrolo[2,3-d]pyrimidine derivatives, which are useful as a Janus kinase (JAK) inhibitor, intermediates thereof, and processes for preparing the intermediates. The present invention provides processes for preparing 3-[(3S, 4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile using salts of (3S,4R)-1-benzyl-3-methyl-1,6-diazaspiro[3.4]octane with organic acids.

公开(公告)号：US20250084106A1

公开(公告)日：2025-03-13

申请号：US18960075

申请日：2024-11-26

Applicant: Japan Tobacco Inc. ,  LEO Pharma A/S

Inventor： Hiromu Takiguchi ,  Akinobu Higashi ,  Takashi Inaba ,  Takashi Watanabe ,  Tsubasa Takeichi ,  Anders Klarskov Petersen ,  Per Vedsoe ,  Kim Lebek Jensen ,  Jan Bornholdt ,  Soren Ebdrup

IPC: C07D519/00 ,  C07C271/22 ,  C07D487/10

Abstract: The present invention provides processes for preparing 7H-pyrrolo[2,3-d]pyrimidine derivatives, which are useful as a Janus kinase (JAK) inhibitor, intermediates thereof, and processes for preparing the intermediates. The present invention provides processes for preparing 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile using salts of (3S,4R)-1-benzyl-3-methyl-1,6-diazaspiro[3.4]octane with organic acids.

公开(公告)号：US10981877B2

公开(公告)日：2021-04-20

申请号：US16319938

申请日：2017-07-28

Applicant: Japan Tobacco Inc.

Inventor： Takahisa Motomura ,  Masafumi Inoue ,  Hirotsugu Ito ,  Takuya Matsuo ,  Koichi Suzawa ,  Hiroshi Yamamoto ,  Tsubasa Takeichi ,  Yasuyuki Kajimoto ,  Takashi Inaba ,  Takao Ito ,  Takahiro Yamasaki ,  Yukishige Ikemoto

IPC: C07D231/12 ,  C07C45/64 ,  C07C43/23 ,  B01J23/44 ,  B01J31/02

Abstract: A production method of a compound represented by the formula [I]: or a pharmaceutically acceptable salt thereof, or a hydrate thereof.