A manufacturing machine and method for the production of a cartridge for an electronic cigarette can include a first assembling drum which is mounted rotatable around a first rotation axis and has at least one first seat which is designed to house a tube and a second seat which is axially aligned with the first seat and is designed to house a support of a heating device; a first feeding station in which a tube is fed into the first seat; a second feeding station in which a support of a heating device is fed into the second seat; and a first welding station which is arranged downstream of the first feeding station and of the second feeding station and is provided with a first welding device, which, through a welded joint, connects a tube carried by the first seat to a support carried by the second seat.