Systems and methods for reducing speckle while maintaining frame rate are disclosed. Multiple sub-images associated with different receive angles are acquired for a single transmit/receive event at an observation angle. The sub-images are compounded to generate a final image with reduced speckle. In some examples, multiple sub-images from multiple transmit/receive events are compounded to generate the final image. The observation angle and/or the receive angles may vary between transmit/receive events in some examples.