Invention Grant
- Patent Title: Fluorescent probe for detecting carboxypeptidase activity
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Application No.: US17298477Application Date: 2019-12-02
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Publication No.: US12221649B2Publication Date: 2025-02-11
- Inventor: Yasuteru Urano , Mako Kamiya , Yugo Kuriki
- Applicant: The University of Tokyo
- Applicant Address: JP Tokyo
- Assignee: The University of Tokyo
- Current Assignee: The University of Tokyo
- Current Assignee Address: JP Tokyo
- Agency: Knobbe, Martens, Olson & Bear, LLP
- Priority: JP2018-225735 20181130
- International Application: PCT/JP2019/047000 WO 20191202
- International Announcement: WO2020/111279 WO 20200604
- Main IPC: C12Q1/37
- IPC: C12Q1/37 ; C07F9/655 ; C07F9/6561 ; C09K11/06 ; G01N21/64 ; G01N33/542

Abstract:
A compound is represented by the following general formula (I): The compound or a salt thereof provides a fluorescent probe for detecting carboxypeptidase activity In the formula, R1 represents an alkyl group having 1 to 6 carbon atoms or an alkoxy group having 1 to 6 carbon atoms; T represents an amino acid residue or a residue of an amino acid derivative; S represents a C-terminal amino acid residue. represents a fluorophore, and the fluorophore is a fluorophore in which an absorption/fluorescence wavelength greatly changes or a quenched state changes to a fluorescent state by elimination of the —P(═O)(—R1)-T-S moiety.
Public/Granted literature
- US20220017940A1 FLUORESCENT PROBE FOR DETECTING CARBOXYPEPTIDASE ACTIVITY Public/Granted day:2022-01-20
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