A leakage current detection and interruption device includes a switch module configured to control electrical connection between input and output ends of power supply lines; a leakage current detection module configured to generate a leakage fault signal in response to a leakage current in the power supply lines; a leakage-responsive drive module configured to drive the switch module to disconnect the electrical connection in response to the leakage fault signal; a fault-responsive drive module configured to drive the switch module to disconnect the electrical connection in response to a fault in the leakage-responsive drive module; and a self-test module configured to generate a self-test signal and to generate a self-test fault signal in response to a fault in the leakage current detection module and/or the leakage-responsive drive module. By providing the fault-responsive drive module, the device can automatically disconnect the electrical power when the leakage-responsive drive module has a fault.