Invention Grant
- Patent Title: Nucleic acids encoding modified FGF-21 polypeptides, vectors and cells containing, and use thereof
-
Application No.: US17555633Application Date: 2021-12-20
-
Publication No.: US12247058B2Publication Date: 2025-03-11
- Inventor: Paul E. Morin , Daniel Cohen , Ranjan Mukherjee , Timothy P. Reilly , Rose C. Christian , Dasa Lipovsek , Ray Camphausen , John Krupinski
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee Address: US NJ Princeton
- Agency: Baker, Donelson, Bearman, Caldwell & Berkowitz PC
- Agent Robin L. Teskin
- Main IPC: C12N15/12
- IPC: C12N15/12 ; A61K38/18 ; A61K45/06 ; A61K47/60 ; A61K47/64 ; C07K14/50 ; C12N5/10 ; A61K38/00
Abstract:
Nucleic acids encoding modified FGF-21 polypeptides, optionally containing at least one non-codon encoding a naturally-encoded amino acid, and vectors and cells containing are provided. These nucleic acids can be used to express the modified FGF-21 polypeptide encoded thereby. The expressed FGF-21 polypeptides may be used as therapeutics, e.g., in the treatment of diseases associated with fibrosis.
Public/Granted literature
- US20220185856A1 Methods of treating diseases associated with fibrosis using modified FGF-21 polypeptides Public/Granted day:2022-06-16
Information query
IPC分类:
