The present invention relates to guidance during a medical intervention. In order to provide an improved navigation support with a facilitated setup, a system (10) for navigation support is provided. An image data input (12) receives a plurality of acquired 2D X-ray images of a subject's body from different angles. A set of markers, which are visible in X-ray images and which are detectable by a navigation system, is assigned to the subject. A marker detecting arrangement (16) is provided that detects a current spatial location of the markers assigned to the subject. A data processor (14) reconstructs a 3D volume of the subject based on the plurality of 2D X-ray images. At least a part of the markers is arranged outside the volume covered by the reconstructed 3D volume of the subject, while the markers are visible in the 2D X-ray images. The data processor (14) identifies the markers in the 2D X-ray images based on image data of the plurality of 2D X-ray images outside the 3D volume and determines a spatial location of the markers in relation to the 3D volume of the subject. The data processor (14) also registers the reconstructed 3D volume of the subject to a current spatial position of the subject based on the detected current spatial location of the markers and the determined spatial location of the markers in relation to the 3D volume of the subject. An output interface (18) provides the registered reconstructed 3D volume for navigation.