A device for occluding flow of materials is formed as a simple structure permitting a compact delivery configuration which may shift to an expanded deployment configuration. The device has at least one expandable portion formed of a plurality of elongated longitudinally extending frame elements. The frame elements may be spaced apart to define spaces therebetween, and a flexible occlusive material may be provided to block flow of material through such spaces. A flexible occlusive material may form one of two expandable portions of the device without the need for frame elements.