This disclosure provides systems, methods, and devices for wireless communication that support improved routing of image sensors that share a PHY within different secure domains. In a first aspect, a device may receive a packet from an image sensor along a physical data connection. The device may determine a virtual channel associated with the packet and may determining a secure domain for the packet based on the virtual channel. The first secure domain may be selected from a plurality of secure domains accessible via the physical data connection, such as based on a mapping maintained by the device. The device may then route the packet within the first secure domain such that further processing and storage of the packet occurs within the first secure domain, such as within a context base associated with the first secure domain. Other aspects and features are also claimed and described.