Invention Grant
- Patent Title: Transthyretin immunoglobulin fusions
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Application No.: US16753216Application Date: 2018-10-03
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Publication No.: US12269898B2Publication Date: 2025-04-08
- Inventor: Kenneth Walker
- Applicant: AMGEN INC.
- Applicant Address: US CA Thousand Oaks
- Assignee: AMGEN INC.
- Current Assignee: AMGEN INC.
- Current Assignee Address: US CA Thousand Oaks
- Agent Raymond M. Doss
- International Application: PCT/US2018/054237 WO 20181003
- International Announcement: WO2019/070901 WO 20190411
- Main IPC: C07K19/00
- IPC: C07K19/00 ; A61K39/395 ; A61P35/00 ; C07K14/47 ; C07K16/28 ; C07K16/00 ; C12N15/63
Abstract:
The present invention relates to transthyretin (TTR) fusions useful in the dimerization and tetramerization of antibodies and antibody fragments, such as Fabs. The TTR fusions proteins described herein are particularly useful in increasing antibody avidity and in enhancing antigen clustering. Methods for treating diseases using the fusion proteins of the present invention are described herein.
Public/Granted literature
- US20200317795A1 TRANSTHYRETIN IMMUNOGLOBULIN FUSIONS Public/Granted day:2020-10-08
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