Invention Grant
- Patent Title: Combination serotonin specific reuptake inhibitor and serotonin 1A receptor partial agonist for reducing L-DOPA-induced dyskinesia
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Application No.: US17240969Application Date: 2021-04-26
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Publication No.: US12285426B2Publication Date: 2025-04-29
- Inventor: Christopher Roy Bishop , Anthony West , Fredric Manfredsson
- Applicant: The Research Foundation for The State University of new York , Rosalind Franklin University of Medicine and Science , Board of Trustees of Michigan State University
- Applicant Address: US NY Binghamton; US IL North Chicago; US MI East Lansing
- Assignee: The Research Foundation for The State University of new York,Rosalind Franklin University of Medicine and Science,Board of Trustees of Michigan State University
- Current Assignee: The Research Foundation for The State University of new York,Rosalind Franklin University of Medicine and Science,Board of Trustees of Michigan State University
- Current Assignee Address: US NY Binghamton; US IL North Chicago; US MI East Lansing
- Agency: Hoffberg & Asociates
- Agent Steven M. Hoffberg
- Main IPC: A61K31/496
- IPC: A61K31/496 ; A61K9/00 ; A61K31/05 ; A61K31/13 ; A61K31/198 ; A61K31/4545 ; A61K31/495 ; A61K31/55 ; A61K45/06 ; A61P25/16
Abstract:
A method of treating and attenuating L-DOPA-induced dyskinesia, comprising administering an effective dose of at least one pharmacological agent, e.g., vilazodone, having serotonin-specific reuptake inhibition (SSRI) and serotonin receptor 1A (5-HT1AR) partial agonism activity, in conjunction with L-DOPA. Other agents, such as an L-DOPA decarboxylase inhibitor, e.g., carbidopa, or other adjunct treatments may also be provided.
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