Invention Grant
- Patent Title: Substituted pyridines as DNMT1 inhibitors
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Application No.: US18358998Application Date: 2023-07-26
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Publication No.: US12285436B2Publication Date: 2025-04-29
- Inventor: Andrew B. Benowitz , David T. Fosbenner , Bryan Wayne King , Stuart Paul Romeril , Megan Ketchum , Todd Koretke , Elizabeth Ann Moroz , Grace Price
- Applicant: GlaxoSmithKline Intellectual Property Development Limited
- Applicant Address: GB Stevenage
- Assignee: GlaxoSmithKline Intellectual Property Development Limited
- Current Assignee: GlaxoSmithKline Intellectual Property Development Limited
- Current Assignee Address: GB Stevenage
- Agent W. Brett Satuffer
- Main IPC: A61K31/675
- IPC: A61K31/675 ; A61K31/44 ; A61P35/02 ; C07D213/85 ; C07F9/58
Abstract:
The invention relates to substituted pyridine derivatives that are inhibitors of the activity of DNA methyltransferase 1 (DNMT1). The invention also relates to pharmaceutical compositions comprising such compounds and methods of using such compounds in the treatment of cancer, pre-cancerous syndromes, beta haemoglobinopathy disorders, and other diseases associated with inappropriate DNMT1 activity.
Public/Granted literature
- US20240180933A1 SUBSTITUTED PYRIDINES AS DNMT1 INHIBITORS Public/Granted day:2024-06-06
Information query
