公开(公告)号：US12285436B2

公开(公告)日：2025-04-29

申请号：US18358998

申请日：2023-07-26

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Andrew B. Benowitz ,  David T. Fosbenner ,  Bryan Wayne King ,  Stuart Paul Romeril ,  Megan Ketchum ,  Todd Koretke ,  Elizabeth Ann Moroz ,  Grace Price

IPC: A61K31/675 ,  A61K31/44 ,  A61P35/02 ,  C07D213/85 ,  C07F9/58

Abstract: The invention relates to substituted pyridine derivatives that are inhibitors of the activity of DNA methyltransferase 1 (DNMT1). The invention also relates to pharmaceutical compositions comprising such compounds and methods of using such compounds in the treatment of cancer, pre-cancerous syndromes, beta haemoglobinopathy disorders, and other diseases associated with inappropriate DNMT1 activity.