Invention Grant
- Patent Title: Therapeutic vaccine for Hepatitis B virus (HBV) using the HBV PreS1 and/or PreS2, and/or S-HBsAg regions of the HBV envelope protein
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Application No.: US17810480Application Date: 2022-07-01
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Publication No.: US12285482B2Publication Date: 2025-04-29
- Inventor: Edward A. Clark , Che-Leung Law , Deborah Fuller , Michael Gale
- Applicant: University of Washington , ABACUS BIOSCIENCE, INC.
- Applicant Address: US WA Seattle; US WA Sammamish
- Assignee: University of Washington,ABACUS BIOSCIENCE, INC.
- Current Assignee: University of Washington,ABACUS BIOSCIENCE, INC.
- Current Assignee Address: US WA Seattle; US WA Sammamish
- Agency: McDonnell Boehnen Hubert & Berghoff, LLC
- Main IPC: A61K39/29
- IPC: A61K39/29 ; A61K39/00 ; A61P31/20 ; C07K16/28
Abstract:
Compositions including a CD180 binding ligand and a linked Hepatitis B antigen and their use are disclosed. The Hepatitis B antigen includes Hepatitis B virus pre-S1 and/or pre-S2 region of the HBV envelope protein (HBVpreS1/S2Ag), L-HBsAg, MHBsAg, S-HBsAg, or antigenic fragments or mutants thereof.
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