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    Method for preparing multimeric forms of the hepatitis c virus (HCV) envelope glycoprotein 2 (HCV E2)
    3.
    发明授权
    Method for preparing multimeric forms of the hepatitis c virus (HCV) envelope glycoprotein 2 (HCV E2) 有权

    公开(公告)号：US12162906B2

    公开(公告)日：2024-12-10

    申请号：US16337900

    申请日：2017-09-22

    Applicant: MACFARLANE BURNET INSTITUTE FOR MEDICAL RESEARCH AND PUBLIC HEALTH LIMITED

    Inventor： Heidi Drummer ,  Pantelis Poumbourios ,  Robert Center

    IPC: C07K1/113 ,  A61K39/12 ,  A61K39/29 ,  A61P31/14 ,  C07K1/13 ,  C07K1/22 ,  C07K14/005 ,  C07K14/18 ,  G01N33/50 ,  G01N33/569 ,  G01N33/576 ,  A61K39/00 ,  C07K16/10

    Abstract: A method of preparing extracellularly assembled higher order antigen from a native lower order antigen the method comprising the following steps: (i) contacting lower order antigen with a solution comprising a reducing agent for a time and under 5 conditions sufficient to reduce one or more native cysteines; and (ii) removing or diluting the reducing agent or contacting the reduced lower order antigen with an oxidising agent, to elicit assembly of lower order antigen from (i) into an assembled higher order antigen; wherein at least 10% of the lower order antigen is converted to higher order antigen in step (ii) and whereby the assembled higher order antigen 10 displays at least reduced binding to non-neutralizing antibodies compared to the lower order antigen and retains binding to at least one neutralizing antibody. A method of producing a vaccine composition comprising following the steps of the method and then mixing the assembled higher order antigen with a pharmaceutically or physiologically acceptable diluent, carrier or adjuvant. A composition comprising a 15 higher order extracellularly assembled antigen, wherein the assembled antigen displays at least reduced binding to a non-neutralizing antibody compared to a native control higher order antigen. Use of the assembled higher order antigen to stimulate an immune response or for the detection and/or isolation of an immune cell such as a B-cell specific for the antigen.

    HBV VACCINE
    8.
    发明公开
    HBV VACCINE 审中-公开

    公开(公告)号：US20240115694A1

    公开(公告)日：2024-04-11

    申请号：US18206249

    申请日：2023-06-06

    Applicant: Oxford University Innovation Limited

    Inventor： Eleanor BARNES ,  Senthil CHINNAKANNAN

    IPC: A61K39/29 ,  A61K39/39 ,  C07K14/005 ,  C12N7/00

    CPC classification number: A61K39/292 ,  A61K39/39 ,  C07K14/005 ,  C12N7/00 ,  A61K2039/5256

    Abstract: The invention relates to a multi-HBV immunogen viral vector vaccine comprising: a viral vector comprising an immunogen expression cassette, wherein the expression of a protein encoded by the expression cassette is arranged to be driven by a promoter, wherein the immunogen expression cassette encodes: a) HBV Core; b) a modified HBV polymerase (Pmut), wherein the modification is a mutation to wild-type HBV polymerase to substantially remove polymerase function; c) HBV surface antigen (HbsAg); and d) an intergenic sequence that is arranged to cause expression of at least the HBV surface antigen (HbsAg) as a separate protein from the HBV core and the modified HBV polymerase (Pmut), wherein the intergenic sequence is downstream (3′) of the sequences encoding the HBV core and the modified HBV polymerase (Pmut) and upstream (5′) of the sequence encoding the HBV surface antigen (HbsAg); and related compositions, vaccination methods and methods of treatment or prophylaxis of HBV infection.

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