Invention Grant
- Patent Title: Methods and/or use of oligonucleotide conjugates for assays and flow cytometry detections
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Application No.: US17369771Application Date: 2021-07-07
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Publication No.: US12291738B2Publication Date: 2025-05-06
- Inventor: David A. Schwartz , Jimmy Williams , Xinfang Zhao , Chunfang Zhao , William B. Busa , Stephen J. Kron , Amy Catherine Flor
- Applicant: The University of Chicago , EMD Millipore Corporation
- Applicant Address: US IL Chicago; US MA Burlington
- Assignee: The University of Chicago,EMD Millipore Corporation
- Current Assignee: The University of Chicago,EMD Millipore Corporation
- Current Assignee Address: US IL Chicago; US MA Burlington
- Agency: Norton Rose Fulbright US LLP
- Main IPC: C12Q1/6804
- IPC: C12Q1/6804 ; C07H21/00 ; C12Q1/6834

Abstract:
The present disclosure is directed to methods and/or uses of oligonucleotide conjugates for assays and flow cytometry detections and related systems and/or kits. Certain methods are directed to a method for detecting one or more biological targets of a sample in a detection assay, comprising: providing a molecular probe, comprising a binding moiety and an oligonucleotide sequence, to a sample comprising one or more biological targets; binding the one or more biological targets with the binding moiety; providing a detectable component to the sample, wherein the detectable component comprises a signal generating moiety conjugated to an oligonucleotide sequence complementary to the oligonucleotide sequence of the molecular probe; hydridizing the oligonucleotide sequence of the target-bound molecular probe to the detectable component; and detecting a signal generated from the hydridized detectable component. Various other embodiments, applications etc. are disclosed herein.
Public/Granted literature
- US20220170073A1 METHODS AND/OR USE OF OLIGONUCLEOTIDE CONJUGATES FOR ASSAYS AND FLOW CYTOMETRY DETECTIONS Public/Granted day:2022-06-02
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