Invention Grant
- Patent Title: Naphthyridine compounds and uses thereof
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Application No.: US17156384Application Date: 2021-01-22
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Publication No.: US12297210B2Publication Date: 2025-05-13
- Inventor: Terry Kellar , Jun Liang , Sushant Malhotra , Rohan V. Mendonca , Michael Siu , Craig Stivala , John C. Tellis , BinQing Wei , Bryan K. Chan , Lewis J. Gazzard , Timothy Heffron , Graham Jones , Michael Lainchbury , Andrew Madin , Eileen Mary Seward , Matthew W. Cartwright , Emanuela Gancia , David Favor , Kin Chiu Fong , Andrew Good , Yonghan Hu
- Applicant: Genentech, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Genentech, Inc.
- Priority: WOPCT/CN2018/096781 20180724
- Main IPC: C07D519/00
- IPC: C07D519/00 ; A61P37/04 ; C07D471/04
Abstract:
Naphthyridine compounds of formula (I): variations thereof, and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the naphthyridine compounds.
Public/Granted literature
- US20210277024A1 NAPHTHYRIDINE COMPOUNDS AND USES THEREOF Public/Granted day:2021-09-09
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