发明申请
- 专利标题: Gene coding for the measles virus mutant antigen
- 专利标题(中): 基因编码麻疹病毒突变抗原
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申请号: US09873233申请日: 2001-06-05
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公开(公告)号: US20020146434A1公开(公告)日: 2002-10-10
- 发明人: Shigeharu Ueda , Michiko Watanabe , Hitomi Kawanish
- 申请人: The Research Foundation for Microbial Diseases of Osaka University
- 申请人地址: null
- 专利权人: The Research Foundation for Microbial Diseases of Osaka University
- 当前专利权人: The Research Foundation for Microbial Diseases of Osaka University
- 当前专利权人地址: null
- 优先权: JP9-184285 19970604
- 主分类号: C07H021/04
- IPC分类号: C07H021/04 ; A61K039/12 ; A61K039/165 ; C12N007/00 ; C12N007/01 ; C07K005/00 ; C07K007/00 ; C07K016/00 ; C07K017/00 ; A61K038/00 ; C07K001/00 ; C07K014/00
摘要:
Disclosed is a measles virus mutant antigen, comprising at least one protein antigen selected from the group consisting of (I) a measles virus mutant H protein antigen and (II) a measles virus mutant F protein antigen, the measles virus mutant H protein antigen (I) being at least one member selected from the group consisting of the whole protein and fragmentary peptides identified with the positional amino acid numbers of either SEQ ID NO: 2 or SEQ ID NO: 10; and the measles virus mutant F protein antigen (II) 4 being at least one member selected from the group consisting of the whole protein and fragmentary peptides identified with the positional amino acid numbers of either SEQ ID NO: 18 or SEQ ID NO: 20. Also disclosed is a measles virus mutant gene coding for the measles virus mutant antigen. By the use of the measles virus mutant antigen or the gene coding for the same of the present invention, it has become possible to provide efficiently and economically a live attenuated measles vaccine or gene vaccine which is adapted for an epidemic strain of measles virus, and a diagnostic reagent capable of accurately detecting infections with an epidemic strain of measles virus.
公开/授权文献
- US06605284B2 Gene coding for the measles virus mutant antigen 公开/授权日:2003-08-12
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