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    Outer membrane vesicle (omv) vaccine comprising n. meningitidis serogroup b outer membrane proteins
    1.
    发明申请
    Outer membrane vesicle (omv) vaccine comprising n. meningitidis serogroup b outer membrane proteins 有权
    外膜囊泡（omv）疫苗，包括n。 脑膜炎血清群b外膜蛋白

    公开(公告)号：US20040249125A1

    公开(公告)日：2004-12-09

    申请号：US10181600

    申请日：2003-03-31

    发明人： Mariagrazia Pizza ,  Rino Rappuoli ,  Marzia Monica Giuliani

    IPC分类号： A61K039/00 ,  A61K039/38 ,  C07K001/00 ,  C07K014/00 ,  C07K017/00

    CPC分类号： A61K39/095 ,  A61K2039/54 ,  A61K2039/55505 ,  A61K2039/6068 ,  A61K2039/70 ,  Y02A50/466

    摘要： A composition comprising (a) Neisseria meningitidis serogroup B outer membrane vesicles (OMVs), and (b) an immunogenic component selected from other Neisseria proteins, or immunogenic fragments thereof. Component (b) preferably includes a protein from a different NmB strain from that from which the OMV of component (a) is derived. The OMVs are preferably obtained by deoxycholate extraction. Optionally, the composition may also comprise a protective antigen against other pathogens.

    摘要翻译： 一种组合物，其包含（a）脑膜炎奈瑟氏球菌血清群B外膜囊泡（OMV））和（b）选自其他奈瑟氏球菌蛋白质的免疫原性成分或其免疫原性片段。 组分（b）优选包括来自与组分（a）的OMV得自其的不同NmB应变的蛋白质。 OMV优选通过脱氧胆酸提取获得。 任选地，组合物还可以包含抗其他病原体的保护性抗原。

    Plant genes encoding trehalose metabolism enzymes
    2.
    发明申请
    Plant genes encoding trehalose metabolism enzymes 有权
    植物基因编码海藻糖代谢酶

    公开(公告)号：US20040229364A1

    公开(公告)日：2004-11-18

    申请号：US10365970

    申请日：2003-02-13

    发明人： Perry G. Caimi ,  Saverio Carl Falco ,  Anthony J. Kinney ,  J. Antoni Rafalski ,  Zude Weng

    IPC分类号： C12N015/29 ,  C12P021/00 ,  C12N015/00 ,  C07H021/04 ,  C12N015/82 ,  C12N015/09 ,  C12N015/63 ,  C07K001/00 ,  C07K014/00

    CPC分类号： C12Y301/03012 ,  C07H21/04 ,  C12N9/16 ,  C12N15/8273

    摘要： This invention relates to isolated nucleic acid fragments encoding trehalose metabolism enzymes, more specifically, alpha, alpha-trehalase, alpha, alpha-trehalose-phosphate synthase or trehalose-6-phosphate phosphatase. The invention also relates to the construction of a recombinant DNA construct encoding all or a portion of the alpha, alpha-trehalase, alpha, alpha-trehalose-phosphate synthase or trehalose-6-phosphate phosphatase, in sense or antisense orientation, wherein expression of the recombinant DNA construct results in production of altered levels of the alpha, alpha-trehalase, alpha, alpha-trehalose-phosphate synthase or trehalose-6-phosphate phosphatase in a transformed host cell.

    摘要翻译： 本发明涉及编码海藻糖代谢酶，更具体地，α，α-海藻糖酶，α，α-海藻糖 - 磷酸合成酶或海藻糖-6-磷酸磷酸酶的分离的核酸片段。 本发明还涉及在正义或反义方向上构建编码α，α-海藻糖酶，α，α-海藻糖-6-磷酸磷酸酶的全部或部分的重组DNA构建体，其中表达 重组DNA构建体导致转化的宿主细胞中α，α-海藻糖酶，α，α-海藻糖磷酸合酶或海藻糖-6-磷酸磷酸酶水平的变化。

    Anti-paratopic antibody as an immunogen
    5.
    发明申请
    Anti-paratopic antibody as an immunogen 审中-公开
    抗副交叉抗体作为免疫原

    公开(公告)号：US20040224310A1

    公开(公告)日：2004-11-11

    申请号：US10864526

    申请日：2004-06-10

    发明人： Roland Keith McGready

    IPC分类号： C12Q001/70 ,  C07K001/00 ,  C07K016/00 ,  C07K017/00 ,  A61K039/395 ,  C07K014/00

    CPC分类号： C07K16/4225 ,  A61K39/00 ,  C07K16/1045

    摘要： The present invention provides a method of manufacture of an anti-paratopic antibody comprising the steps of: (1) selecting from a pool of antibodies occurring in one species a prototypic set the members of which are effective in binding a specific antigen (or antigen epitope), and (2) utilizing one or more members of said prototypic set, or paratopic fragments thereof, as an immunogen in a host of a different species, or in an in vitro incubation system comprising cells derived from the same or a different species, to produce antibodies having a characteristic which is anti-paratopic with respect to said immunogen to produce a synthetic replicate of the specific antigen or epitope. Antigen (or antigen epitope), and monoclonal antibodies. vaccines and processes of immunization employing the product of the method of manufacture are also described.

    摘要翻译： 本发明提供了一种制备抗副替代抗体的方法，包括以下步骤：（1）从存在于一个物种中的抗体库中选择一个原型组，其成员在结合特异性抗原（或抗原表位 ），和（2）利用所述原型组或其副变构片段的一个或多个成员作为不同物种宿主中的免疫原，或在包含衍生自相同或不同物种的细胞的体外孵育系统中， 以产生具有相对于所述免疫原的抗副交叉特征的抗体，以产生特异性抗原或表位的合成重复。 抗原（或抗原表位）和单克隆抗体。 还描述了使用制造方法的产品的疫苗和免疫方法。

    PH-dependent polypeptide aggregation and its use
    7.
    发明申请
    PH-dependent polypeptide aggregation and its use 审中-公开
    PH依赖多肽聚集及其应用

    公开(公告)号：US20040192887A1

    公开(公告)日：2004-09-30

    申请号：US10397059

    申请日：2003-03-25

    发明人： Ralph Zahn

    IPC分类号： C07K016/00 ,  C12Q001/70 ,  G01N033/53 ,  C07K007/00 ,  C07K017/00 ,  A61K038/04 ,  C07K001/00 ,  C07K014/00 ,  C07K005/00

    CPC分类号： C07K14/47

    摘要： The invention provides an alternative method of reversible aggregation and/or dissociation of polypeptides. Proteins or polypeptides according to the invention have an inherent aggregation capability, wherein the aggregation is an oligomerization of the polypeptide that is based on the presence and the strucuture of peptide repeats localized in a flexibly disordered domain of this polypeptide. The flexibly disordered domain comprising the peptide repeats preferrably is located in close proximity with the N-terminus of the protein amino acid sequence. Preferably, each of the peptide repeats has a sequence that comprises one to four identical octapeptides with the amino acid sequence: PHGGGWGQ. Preferred proteins are selected from the group comprising cellular prion proteins (PrPC) and engineered polypeptides or fusion proteins with a respective inherent reversible aggregation and dissociation capability. Because of the new mechanism of aggregation, the oligomerization reaction of the protein is reversible in a fluidic environment depending on the pH of this fluidic environment. Oligomerization occurs at a pH of 6.2 to 7.8, and the dissociation into monomers is reported to be at a pH range of 4.5 to 5.5. 1

    摘要翻译： 本发明提供了多肽的可逆聚集和/或解离的替代方法。 根据本发明的蛋白质或多肽具有固有的聚集能力，其中聚集是多肽的寡聚化，其基于定位于该多肽的柔性无序结构域中的肽重复序列的存在和结构。 优选地，包含肽重复序列的柔性无序结构域位于蛋白质氨基酸序列的N-末端附近。 优选地，每个肽重复序列具有包含1-4个与氨基酸序列PHGGGWGQ相同的八肽的序列。 优选的蛋白质选自包含细胞朊蛋白（PrP））和具有相应固有的可逆聚集和解离能力的工程改造的多肽或融合蛋白。 由于聚合的新机制，蛋白质的低聚反应在流体环境中是可逆的，这取决于该流体环境的pH。 低聚发生在6.2至7.8的pH下，据报导单体的解离在4.5至5.5的pH范围内。

    Polypeptides toxic to nematodes and methods of use
    8.
    发明申请
    Polypeptides toxic to nematodes and methods of use 审中-公开
    对线虫有毒的多肽和使用方法

    公开(公告)号：US20040185566A1

    公开(公告)日：2004-09-23

    申请号：US10392432

    申请日：2003-03-19

    发明人： Peter Salamone

    IPC分类号： C12N015/82 ,  C07H021/04 ,  C12N015/87 ,  C12N015/09 ,  C12N015/63 ,  C07K001/00 ,  C07K014/00 ,  C07K016/00 ,  C12N005/04 ,  C12N005/10

    CPC分类号： C07K14/8146 ,  C07K14/4354 ,  C12N9/52 ,  C12N15/8285 ,  Y02A40/164

    摘要： The present invention provides polynucleotides and related polypeptides of a newly discovered serratia metalloprotease (SMP), as well as polynucleotides and related polypeptides of a newly discovered serratia metalloprotease inhibitor (SmaPI). The present invention further relates broadly to the use of the newly discovered SMP as a nematocidal agent, either as an administered agent, or as part of an integrated management system. The polynucleotides can be used to transform plants normally susceptible to free-living or burrowing plant parasitic nematodes, such as those of the genera Ascaris and Radopholus.

    摘要翻译： 本发明提供新发现的沙雷氏菌属金属蛋白酶（SMP）的多核苷酸和相关多肽，以及新发现的沙雷氏菌属金属蛋白酶抑制剂（SmaPI）的多核苷酸和相关多肽。 本发明进一步涉及新发现的SMP作为杀线虫药物作为给药剂或作为综合管理系统的一部分的用途。 多核苷酸可用于转化通常易于自由生活或挖掘植物寄生线虫的植物，例如蛔虫属和蝎尾草属的那些。

    Polynucleotide compositions encoding broad spectrum delta-endotoxins
    9.
    发明申请
    Polynucleotide compositions encoding broad spectrum delta-endotoxins 有权
    编码广谱δ-内毒素的多核苷酸组合物

    公开(公告)号：US20040132975A1

    公开(公告)日：2004-07-08

    申请号：US10739482

    申请日：2003-12-18

    申请人： Monsanto Technology LLC.

    发明人： Thomas Malvar ,  Komarlingam Sukavancaswaran Mohan ,  Sakuntala Sivasupramaniam

    IPC分类号： C07K001/00 ,  C07K014/00 ,  C07K017/00

    CPC分类号： C07K14/325 ,  C07K2319/00 ,  C12N15/8286 ,  Y02A40/162

    摘要： Disclosed are novel synthetically-modified B. thuringiensis chimeric crystal proteins having improved insecticidal activity and broader insect host range against coleopteran, dipteran and lepidopteran insects. Also disclosed are the nucleic acid segments encoding these novel peptides. Methods of making and using these genes and proteins are disclosed as well as methods for the recombinant expression, and transformation of suitable host cells. Transformed host cells and transgenic plants expressing the modified endotoxin are also aspects of the invention.

    摘要翻译： 公开了具有改进的杀虫活性和更广泛的昆虫宿主范围的新型合成修饰的苏云金芽孢杆菌嵌合晶体蛋白，其针对鞘翅目，双翅目和鳞翅目昆虫。 还公开了编码这些新肽的核酸片段。 公开了制备和使用这些基因和蛋白质的方法以及重组表达和合适宿主细胞转化的方法。 转化的宿主细胞和表达修饰的内毒素的转基因植物也是本发明的方面。

    Immunotoxin fusion proteins and means for expression thereof
    10.
    发明申请
    Immunotoxin fusion proteins and means for expression thereof 有权
    免疫毒素融合蛋白及其表达方法

    公开(公告)号：US20040127682A1

    公开(公告)日：2004-07-01

    申请号：US10296085

    申请日：2004-01-13

    发明人： David M Neville ,  Jerry T Thompson ,  Huaizhong Hu ,  Jung-Hee Woo ,  Shenglin Ma ,  Jonathan Mark Hexham ,  Mary Ellen Digan

    IPC分类号： C07K001/00 ,  C07K014/00 ,  C07K017/00

    CPC分类号： C07K19/00 ,  A61K47/6829 ,  A61K47/6849 ,  C07K5/1008 ,  C07K7/06 ,  C07K7/08 ,  C07K14/34 ,  C07K16/2809 ,  C07K2317/24 ,  C07K2317/622 ,  C07K2319/00

    摘要： The present invention described and shown in the specification and drawings provides novel recombinant DT-based immunotoxins, and, more specifically anti-T cell immunotoxin fusion proteins. Also provided are immunotoxins that can be expressed in bacterial, yeast, or mammalian cells. The invention also provides means for expression of the immunotoxin fusion protein. It is emphasized that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.

    摘要翻译： 在说明书和附图中描述和示出的本发明提供了新的重组DT-基免疫毒素，更具体地，提供了抗T细胞免疫毒素融合蛋白。 还提供了可以在细菌，酵母或哺乳动物细胞中表达的免疫毒素。 本发明还提供了表达免疫毒素融合蛋白的方法。 要强调的是，该摘要被提供以符合要求抽象的规则，允许搜索者或其他读者快速确定技术公开的主题。 提交它的理解是，它不会用于解释或限制权利要求的范围或含义。