发明申请
- 专利标题: Novel nucleoside and oligonucleotide analogues
- 专利标题(中): 新型核苷和寡核苷酸类似物
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申请号: US09925673申请日: 2001-08-09
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公开(公告)号: US20020147332A1公开(公告)日: 2002-10-10
- 发明人: Masakatsu Kaneko , Koji Morita , Takeshi Imanishi
- 申请人: SANKYO COMPANY, LIMITED
- 申请人地址: JP Tokyo
- 专利权人: SANKYO COMPANY, LIMITED
- 当前专利权人: SANKYO COMPANY, LIMITED
- 当前专利权人地址: JP Tokyo
- 优先权: JPHEI-11-33863 19990212
- 主分类号: C07H019/04
- IPC分类号: C07H019/04 ; C07H019/06
摘要:
A compound of the formula (1): 1 wherein R1 and R2 are the same or different and represent a hydrogen atom, a hydroxyl protecting group, a phosphate group, or nullP(R3)R4, wherein R3 and R4 are the same or different and represent a hydroxyl group, an amino group, an alkoxy group having from 1 to 4 carbon atoms, a cyanoalkoxy group having from 1 to 5 carbon atoms or an amino group substituted by an alkyl group having from 1 to 4 carbon atoms; A represents an alkylene group having from 1 to 4 carbon atoms and B represents a purin-9-yl group, a 2-oxo-pyrimidin-1-yl group, a substituted purin-9-yl group or a substituted 2-oxo-pyrimidin-1-yl group having a substituent null selected from the group consisting of a hydroxyl group which may be protected, an alkoxy group having from 1 to 4 carbon atoms, a mercapto group which may be protected, an alkylthio group having from 1 to 4 carbon atoms, an alkoxy group having from 1 to 4 carbon atoms, an amino group which may be protected, a mono- or di-alkylamino group which may be substituted by an alkyl group having from 1 to 4 carbon atoms, an alkyl group having from 1 to 4 carbon atoms and a halogen atom; or a salt thereof.
公开/授权文献
- US07335765B2 Nucleoside and oligonucleotide analogues 公开/授权日:2008-02-26
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