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    STABLE TARGET-EDITING GUIDE RNA TO WHICH CHEMICALLY MODIFIED NUCLEIC ACID IS INTRODUCED
    8.
    发明公开
    STABLE TARGET-EDITING GUIDE RNA TO WHICH CHEMICALLY MODIFIED NUCLEIC ACID IS INTRODUCED 审中-公开

    公开(公告)号：US20240093227A1

    公开(公告)日：2024-03-21

    申请号：US18265756

    申请日：2021-12-08

    申请人： FUKUOKA UNIVERSITY ,  DAIICHI SANKYO COMPANY, LIMITED

    发明人： Masatora FUKUDA ,  Makoto KOIZUMI ,  Shinzo IWASHITA

    IPC分类号： C12N15/85 ,  C12N9/78 ,  C12N15/11

    CPC分类号： C12N15/85 ,  C12N9/78 ,  C12N15/11 ,  C12Y305/04 ,  A61K48/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2800/107

    摘要： Provided is an oligonucleotide which may induce an editing activity of ADRC in cell and has excellent stability in a living body. The oligonucleotide includes a first oligonucleotide identifying a target RNA and a second oligonucleotide linked to the 5′-side of the first oligonucleotide. The first oligonucleotide consists of a target-corresponding nucleotide residue, an oligonucleotide of 10 to 24 residues at the 3′-side, and an oligonucleotide of 3 to 6 residues at the 5′-side. The second oligonucleotide has no nucleotide residue corresponding to a nucleotide residue of the target RNA or has a nucleotide residue which does not form a complementary pair at the 3′-end thereof and the number of residue is 3 to 6. The residue at the 3′-side of the target-corresponding nucleotide residue is a 2′-deoxynucleotide residue, and the third nucleotide residue counted in the 3′-direction from the target-corresponding nucleotide in the oligonucleotide at the 3′-side of the target-corresponding nucleotide residue is a 2′-deoxy-2′-fluoronucleotide residue.