Invention Application
US20020155602A1 Vectors, cells and methods for the production of deleterious viral eukaryotic gene transfer vectors
审中-公开
用于产生有害病毒真核基因转移载体的载体，细胞和方法
- Patent Title: Vectors, cells and methods for the production of deleterious viral eukaryotic gene transfer vectors
- Patent Title (中): 用于产生有害病毒真核基因转移载体的载体，细胞和方法
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Application No.: US10123886Application Date: 2002-04-16
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Publication No.: US20020155602A1Publication Date: 2002-10-24
- Inventor: Joseph T. Bruder , Imre Kovesdi , Alena Lizonova
- Applicant: GenVec, Inc.
- Applicant Address: US MD Gaithersburg
- Assignee: GenVec, Inc.
- Current Assignee: GenVec, Inc.
- Current Assignee Address: US MD Gaithersburg
- Main IPC: C12N007/01
- IPC: C12N007/01 ; C12N005/08 ; C12N015/861
Abstract:
The present invention provides a method of in vitro propagation of a viral eukaryotic gene transfer vector comprising a deleterious, i.e., a cytostatic, cytotoxic, or apoptotic, gene in a eukaryotic, e.g., a mammalian, host-production cell, comprising a blocking gene. The blocking gene inhibits the adverse effects of the deleterious gene on the eukaryotic host-production cell. Vectors and cells useful in the context of the present inventive method are also provided.
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