发明申请
US20030008014A1 Truncated apolipoprotein B-containing lipoprotein particles for delivery of compounds to tissues or cells
审中-公开
用于将化合物递送至组织或细胞的截短载脂蛋白B的脂蛋白颗粒
- 专利标题： Truncated apolipoprotein B-containing lipoprotein particles for delivery of compounds to tissues or cells
- 专利标题（中）： 用于将化合物递送至组织或细胞的截短载脂蛋白B的脂蛋白颗粒
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申请号： US09885894申请日： 2001-06-20
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公开(公告)号： US20030008014A1公开(公告)日： 2003-01-09
- 发明人: Gregory S. Shelness
- 主分类号： A61K038/17
- IPC分类号： A61K038/17 ; A61K009/50 ; C07K014/775
摘要：
A lipoprotein compound delivery particle comprises: (a) a lipophilic or amphipathic compound to be delivered (e.g. paclitaxel); (b) at least one polar lipid (this ingredient being optional when the lipophilic or amphipathic compound serves itself as a polar lipid); (c) optionally, at least one neutral lipid; and (d) a truncated apolipoprotein B (apoB) protein having a deleted LDL receptor binding region. Conjugates useful for making such particles, pharmaceutical formulations containing such particles, and methods of using such particles are also described.
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