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2266 条记录 (耗时 0.024 秒)

    Methods for modulating endometrium
    1.
    发明申请
    Methods for modulating endometrium 审中-公开
    调节子宫内膜的方法

    公开(公告)号：US20040266688A1

    公开(公告)日：2004-12-30

    申请号：US10846477

    申请日：2004-05-14

    发明人： Nihar R. Nayak

    IPC分类号： A61K038/17

    CPC分类号： A61K9/0034 ,  A61K38/179

    摘要： The present invention provides methods of modulating the endometrium, including methods for inhibiting pregnancy and methods for treating gynecological bleeding disorders, such as dysfunctional uterine bleeding and endometrial bleeding. The methods generally involve administering to an individual in need thereof a vascular endothelial growth factor (VEGF) antagonist, e.g., a chimeric VEGF blocker, where the VEGF antagonist is administered during the post-menstrual repair phase. The invention further provides chimeric VEGF blockers formulated for use in inhibiting pregnancy and treating gynecological bleeding disorders, as well as kits and delivery systems comprising the formulations.

    Method of diagnosing and treating lens illnesses using human HSF4 gene and coded product thereof
    2.
    发明申请
    Method of diagnosing and treating lens illnesses using human HSF4 gene and coded product thereof 审中-公开
    使用人HSF4基因及其编码产物诊断和治疗晶状体疾病的方法

    公开(公告)号：US20040266677A1

    公开(公告)日：2004-12-30

    申请号：US10610164

    申请日：2003-06-30

    发明人： Xiangyin Kong ,  Landian Hu ,  Lei Bu

    IPC分类号： A61K038/17 ,  C12Q001/68

    CPC分类号： A61K38/1709 ,  C12Q1/6883 ,  C12Q2600/156 ,  G01N33/6893 ,  G01N2800/166

    摘要： The invention has disclosed a method for diagnosis of lens illnesses such as cataract. This method comprises the steps of detecting the HSF4 gene, transcript and/or protein in the subject and comparing it with the normal HSF4 gene, transcript and/or protein to determine whether there is any variation, wherein the variation indicates that the possibility of suffering lens illnesses, such as cataract, in the subject is higher than that in the normal population. The present invention also discloses the method and pharmaceutical composition for treating cataract and other lens illnesses.

    摘要翻译： 本发明公开了一种诊断镜片疾病如白内障的方法。 该方法包括检测受试者中的HSF4基因，转录本和/或蛋白质并将其与正常HSF4基因，转录物和/或蛋白质进行比较以确定是否存在任何变异的步骤，其中变异表明患有痛苦的可能性 患者白内障等镜片疾病高于正常人群。 本发明还公开了治疗白内障和其他晶状体疾病的方法和药物组合物。

    Methods to increase reverse cholesterol transport in the retinal pigment epithelium (RPE) and bruch's membrane (BM)
    4.
    发明申请
    Methods to increase reverse cholesterol transport in the retinal pigment epithelium (RPE) and bruch's membrane (BM) 失效
    增加视网膜色素上皮（RPE）和布鲁奇膜（BM）中逆转胆固醇转运的方法

    公开(公告)号：US20040266663A1

    公开(公告)日：2004-12-30

    申请号：US10794198

    申请日：2004-03-05

    发明人： Daniel M. Schwartz ,  Keith G. Duncan ,  Kathy R. Bailey ,  John P. Kane ,  Brian Y. Ishida

    IPC分类号： A61K038/17 ,  A61K031/56

    CPC分类号： A61K31/685 ,  A61K31/66 ,  A61K38/17 ,  A61K38/1709 ,  A61K2300/00

    摘要： The present invention addresses the treatment of age-related macular degeneration using regulation of pathogenic mechanisms similar to atherosclerosis. In further specific embodiments, compositions that increase reverse cholesterol transport are utilized as therapeutic targets for age-related macular degeneration. In a specific embodiment, the lipid content of the retinal pigment epithelium, and/or Bruch's membrane is reduced by delivering Apolipoprotein A1, particularly a mimetic peptide.

    摘要翻译： 本发明通过调节与动脉粥样硬化相似的致病机制来解决年龄相关性黄斑变性的治疗。 在另外的具体实施方案中，增加反向胆固醇转运的组合物被用作年龄相关性黄斑变性的治疗靶标。 在一个具体的实施方案中，通过递送载脂蛋白A1，特别是模拟肽来减少视网膜色素上皮和/或Bruch's膜的脂质含量。

    Use of antimicrobial proteins and peptides for the treatment of otitis media and paranasal sinusitis
    6.
    发明申请
    Use of antimicrobial proteins and peptides for the treatment of otitis media and paranasal sinusitis 失效
    使用抗菌蛋白和肽治疗中耳炎和鼻旁窦炎

    公开(公告)号：US20040265296A1

    公开(公告)日：2004-12-30

    申请号：US10819714

    申请日：2004-04-06

    发明人： David J. Lim ,  Haa-Yung Lee ,  Paul Webster ,  Ali Andalibi ,  Jian-Dong Li ,  Tomas Ganz

    IPC分类号： A61K038/47 ,  A61K038/42 ,  A61K038/17

    CPC分类号： A61K38/40 ,  A61K38/1729 ,  A61K38/47 ,  A61K2300/00

    摘要： Disclosed herein is a composition and a method for the treatment of otitis media and paranasal sinusitis using human defensins, lysozyme and/or lactoferrin as a new class of non-antibiotic antimicrobials. From studies of otitis media and paranasal sinusitis, it was observed that certain innate immune modulators were important in the bodies response to the infection. Therefore, these innate immune modulators, lysozyme, lactoferrin, and defensins were tested for use as a non-antibiotic treatment for infection, particularly infections such as otitis media and sinusitis.

    摘要翻译： 本文公开了使用人防御素，溶菌酶和/或乳铁蛋白作为新一类非抗生素抗微生物剂治疗中耳炎和鼻旁窦炎的组合物和方法。 从中耳炎和鼻旁窦炎的研究中，观察到某些先天免疫调节剂在身体对感染的反应中是重要的。 因此，这些先天免疫调节剂，溶菌酶，乳铁蛋白和防御素被测试用作感染的非抗生素治疗，特别是感染例如中耳炎和鼻窦炎。

    Regulator of apoptosis and cell proliferation
    8.
    发明申请
    Regulator of apoptosis and cell proliferation 审中-公开
    调节细胞凋亡和细胞增殖

    公开(公告)号：US20040254111A1

    公开(公告)日：2004-12-16

    申请号：US10791860

    申请日：2004-03-04

    发明人： Huang Bing-Ren ,  Zhou Xin-Fu

    IPC分类号： A61K038/17

    CPC分类号： C07K14/4747 ,  C07K16/18

    摘要： This invention relates to a method of regulating apoptosis and/or proliferation in a cell, the method including the step of altering the expression and/or function in the cell of polypeptides based on Apoptosis Related Basic Protein.

    摘要翻译： 本发明涉及一种调节细胞凋亡和/或增殖的方法，所述方法包括基于凋亡相关基因蛋白改变多肽细胞中的表达和/或功能的步骤。

    Hagfish cathelin-associated antimicrobial peptides and genes
    10.
    发明申请
    Hagfish cathelin-associated antimicrobial peptides and genes 审中-公开
    fish鱼相关的抗生素肽和基因

    公开(公告)号：US20040249143A1

    公开(公告)日：2004-12-09

    申请号：US10485278

    申请日：2004-07-26

    发明人： Thomas Uzzell ,  Ann E. Shinnar ,  Michael A. Zasloff

    IPC分类号： A61K038/17 ,  C07K014/47 ,  C07H021/04

    CPC分类号： C07K14/461 ,  A61K38/00

    摘要： The present invention includes Myxine glutinosa cathelin-associated antimicrobial peptides and genes encoding these peptides. The invention also includes compositions an methods for producing these peptides as well as method of preventing and treating microbial infections using these peptides.

    摘要翻译： 本发明包括Myxine粘蛋白相关抗原肽和编码这些肽的基因。 本发明还包括制备这些肽的方法的组合物以及使用这些肽预防和治疗微生物感染的方法。