The present invention relates to a manufacturing method and a structure of organic light-emitting diode display panels. By precisely controlling the positionnullshape and thickness of the organic light-emitting layer of pixels, the conventional cross talk problem can be solved and a better quality and longer lifetime for the OLED can be obtained. This method is to form a plurality of long grooves on a substrate, then fill the grooves with a conducting material to form a plurality of first electrode lines. A cavity matrix is formed on the first electrodes. Each individual cavity of the cavity matrix corresponds to a pixel. An organic light-emitting layer is filled in the cavities. Repeat the above steps three times, and a red-green-blue three-color organic light-emitting matrix can be obtained. A plurality of second electrode lines are formed on the organic light-emitting layer. The second electrode lines are horizontally parallel for connecting the organic light-emitting layer with the same horizontal position. Hence, a full-color organic light-emitting diode display panel can be obtained.