发明申请
US20030060622A1 Process for the preparation of 2'-halo-beta-L-arabinofuranosyl nucleosides 有权
制备2'-卤代-β-L-阿拉伯呋喃糖苷的方法

  • 专利标题: Process for the preparation of 2'-halo-beta-L-arabinofuranosyl nucleosides
  • 专利标题(中): 制备2'-卤代-β-L-阿拉伯呋喃糖苷的方法
  • 申请号: US10112403
    申请日: 2002-03-29
  • 公开(公告)号: US20030060622A1
    公开(公告)日: 2003-03-27
  • 发明人: Marcos Sznaidman
  • 主分类号: C07H019/19
  • IPC分类号: C07H019/19 C07H019/06 C07H019/067 C07H019/073 C07H019/09
Process for the preparation of 2'-halo-beta-L-arabinofuranosyl nucleosides
摘要:
The present invention is directed to the process for the preparation of 2null-deoxy-2null-halo-null-L-arabinofuranosyl nucleosides, and in particular, 2null-deoxy-2null-fluoro-null-L-arabinofuranosyl thymine (L-FMAU), from L-arabinose, which is commercially available and less expensive than L-ribose or L-xylose, in ten steps. All of the reagents and starting materials are inexpensive and no special equipment is required to carry out the reactions.
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