A method of manufacturing a fatigue life enhanced product from a plurality of workpiece parts. At least one fatigue enhancing operation is performed on a first workpiece at a first work station. At least one fatigue enhancing operation is performed on a second workpiece at a second work station. The first and second workpieces are transferred to a first assembly station, where the workpieces are joined to form a fatigue life enhanced product. Aerostructures manufactured according to the method may include components fabricated at different locations to have fatigue life enhancing properties, especially in bounding material adjacent to holes designed to accommodate fasteners. By use of the method, the final assembly step can thus avoid the necessity to include the processing of holes to enhance fatigue life, since this step has been performed prior to bringing components into position to be joined in the final shape or assembly of the airframe.